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Prevalence of statin intolerance: a meta-analysis. Eur Heart J. 2022; 43(34):3213-3223.<br>3.Lin J, Ji Y, Wang G, et al. Efficacy and safety of ongericimab in Chinese patients with heterozygous familial hypercholesterolemia: a randomized, double-blind, placebo-controlled phase 3 trial[J]. 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6.1%\u3002\u540c\u6642\uff0c\u8a72\u806f\u5408\u7642\u6cd5\u5728\u665a\u671fHCC\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u826f\u597d\uff0c\u6bd2\u6027\u8b5c\u8207\u5df2\u77e5\u55ae\u85e5\u6bd2\u6027\u8b5c\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u4fe1\u865f\u3002<\/p>\n\n\n\n<p><strong>\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u4e2d\u5c71\u91ab\u9662\u6a0a\u5609\u9662\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u514d\u75ab\u806f\u5408\u6297\u8840\u7ba1\u751f\u6210\u6cbb\u7642\u5df2\u6210\u70ba\u665a\u671f\u809d\u764c\u4e00\u7dda\u6cbb\u7642\u57fa\u77f3\u3002HEPATORCH\u7814\u7a76\u5145\u5206\u9a57\u8b49\u4e86\u7279\u745e\u666e\u5229\u55ae\u6297\u5728\u4e2d\u570b\u809d\u764c\u60a3\u8005\u4e2d\u7684\u81e8\u5e8a\u7642\u6548\uff0c\u806f\u5408\u8c9d\u4f10ORR\u9ad8\u905425.3%\uff0c\u4e2d\u4f4dPFS\u70ba5.8\u500b\u6708\uff0c\u4e2d\u4f4dOS\u9054\u523020.0\u500b\u6708\u3002\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u8c9d\u4f10\u73e0\u55ae\u6297\u7684TB\u65b9\u6848\u5c07\u9020\u798f\u66f4\u591a\u4e2d\u570b\u665a\u671f\u809d\u764c\u60a3\u8005\u3002\u201d<\/p>\n\n\n\n<p><strong>\u541b\u5be6\u751f\u7269\u7e3d\u7d93\u7406\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9112\u5efa\u8ecd\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u5728\u2018\u5341\u5168\u5be6\u7f8e\u2019\u7684\u57fa\u790e\u4e0a\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u7e7c\u7e8c\u7a81\u7834\uff0c\u8fce\u4f86\u4e86\u5176\u7b2c11\u500b\u9069\u61c9\u75c7\u7684\u6b63\u5f0f\u7372\u6279\uff0c\u9019\u8b93\u6211\u5011\u500d\u611f\u632f\u596e\uff01\u4f5c\u70ba\u5168\u7403\u809d\u764c\u75be\u75c5\u8ca0\u64d4\u6700\u91cd\u7684\u570b\u5bb6\uff0c\u6211\u570b\u809d\u764c\u60a3\u8005\u9577\u671f\u9762\u81e8\u6cbb\u7642\u9078\u64c7\u6709\u9650\u7684\u56f0\u5883\u3002\u541b\u5be6\u751f\u7269\u9577\u671f\u805a\u7126\u5168\u7403\u809d\u764c\u6cbb\u7642\u9818\u57df\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u91dd\u5c0d\u4e0d\u540c\u75c5\u7a0b\u4eba\u7fa4\u4f48\u5c40\u4e86\u904b\u7528\u591a\u5143\u806f\u7528\u7b56\u7565\u7684\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u70ba\u809d\u764c\u60a3\u8005\u63d0\u4f9b\u66f4\u7cbe\u51c6\u3001\u66f4\u8c50\u5bcc\u7684\u6cbb\u7642\u9078\u64c7\u3002\u6211\u5011\u5c07\u6301\u7e8c\u81f4\u529b\u65bc\u8a72\u9818\u57df\u5167\u7684\u85e5\u7269\u5275\u65b0\uff0c\u70ba\u4eba\u985e\u6297\u64ca\u809d\u764c\u4e8b\u696d\u6ce8\u5165\u66f4\u5f37\u5927\u7684\u2018\u4e2d\u570b\u667a\u6167\u2019\u3002\u201d<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">\u3010\u53c3\u8003\u6587\u737b\u3011<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\">1. Hepatocellular carcinoma. Nat Rev Dis Primers. 2021;7(1):7.<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\">2. Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-263.<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\">3. Zheng RS, Chen R, Han BF, et al. Zhonghua Zhong Liu Za Zhi. 2024;46(3):221-231.<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\">4. \u300a\u9776\u514d\u8054\u5408\u5c40\u90e8\u6cbb\u7597 \u4e2d\u665a\u671f\u809d\u7ec6\u80de\u764c\u4e2d\u56fd\u4e13\u5bb6\u5171\u8bc6\u300b, \u809d\u764c\u7535\u5b50\u6742\u5fd7, 2023, 10(3): 1-11<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\">5. Zeng H, Chen W, Zheng R, et al. Changing cancer survival in China during 2003-15: a pooled analysis of 17 population-based cancer registries. Lancet Glob Health. 2018;6(5):e555-e567.<\/h6>\n\n\n\n<p><\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><em>1.\u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/em><\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><em>2. 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class=\"wp-block-heading\"><em>1. \u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/em><\/h6>\n\n\n\n<h6 class=\"wp-block-heading\"><em>2. \u82e5\u60a8\u60f3\u77ad\u89e3\u5177\u9ad4\u75be\u75c5\u8a3a\u7642\u8cc7\u8a0a\uff0c\u8acb\u9075\u5f9e\u91ab\u7642\u885b\u751f\u5c08\u696d\u4eba\u58eb\u7684\u610f\u898b\u8207\u6307\u5c0e\u3002<\/em><\/h6>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u95dc\u65bc\u5229\u5967\u88fd\u85e5<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u5229\u5967\u88fd\u85e5\u662f\u4e00\u5bb6\u5168\u7403\u6027\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u901a\u904e\u5275\u65b0\u6539\u5584\u76ae\u819a\u75c5\u60a3\u8005\u7684\u6a19\u6e96\u6cbb\u7642\uff0c\u540c\u6642\u9084\u70ba\u764c\u75c7\u60a3\u8005\u548c\u5176\u4ed6\u5c08\u79d1\u60a3\u8005\u63d0\u4f9b\u6297\u51dd\u8840\u6cbb\u7642\u3002\u5229\u5967\u88fd\u85e5\u7531\u4e3b\u8981\u80a1\u6771\u5229\u5967\u57fa\u91d1\u6703\u548c\u81ea2021\u5e74\u8d77\u7684Nordic 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href=\"https:\/\/www.leo-pharma.com\">https:\/\/www.leo-pharma.com<\/a>\u3002<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5229\u5967\u88fd\u85e5\u5c07\u8ca0\u8cac\u7279\u745e\u666e\u5229\u55ae\u6297\u5728\u6b50\u76df\uff08EU\uff09\u53ca\u6b50\u6d32\u7d93\u6fdf\u5340\uff08EEA\uff09\u6240\u6709\u6210\u54e1\u570b\uff0c\u4ee5\u53ca\u745e\u58eb\u3001\u82f1\u570b\u7684\u5206\u92b7\u3001\u63a8\u5ee3\u3001\u92b7\u552e\u7b49\u5de5\u4f5c\uff0c\u76ee\u524d\u6700\u591a\u53ef\u905432\u500b\u570b\u5bb6\u3002<\/p>\n","protected":false},"author":4,"featured_media":3257,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[],"class_list":["post-3262","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-21"],"yoast_head":"\n<title>\u541b\u5be6\u751f\u7269\u5ba3\u4f48\u8207\u5229\u5967\u88fd\u85e5\u5c31\u7279\u745e\u666e\u5229\u55ae\u6297\u6b50\u6d32\u5546\u696d\u5316\u9054\u6210\u5408\u4f5c 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2022\u767c\u4f48\u7684\u8cc7\u6599\u986f\u793a\uff0c2022\u5e74\u9f3b\u54bd\u764c\u5728\u5168\u7403\u7bc4\u570d\u5167\u78ba\u8a3a\u7684\u65b0\u767c\u75c5\u4f8b\u6578\u8d85\u904e12\u842c<sup>1<\/sup>\u3002\u7279\u745e\u666e\u5229\u55ae\u6297\u662f\u300a\u7f8e\u570b\u570b\u5bb6\u7d9c\u5408\u764c\u75c7\u7db2\u8def\uff08NCCN\uff09\u982d\u9838\u90e8\u816b\u7624\u81e8\u5e8a\u5be6\u8e10\u6307\u53572025.V1\u300b\u4e2d\u63a8\u85a6\u7528\u65bc\u5fa9\u767c\/\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u5168\u7dda\u6cbb\u7642\u7684\u552f\u4e00\u9996\u9078\u85e5\u7269<sup>2<\/sup>\u3002<\/p>\n\n\n\n<p>\u672c\u6b21\u4e0a\u5e02\u7533\u8acb\u7684\u6279\u51c6\u4e3b\u8981\u57fa\u65bcJUPITER-02\uff08\u4e00\u9805\u91dd\u5c0d\u4e00\u7dda\u6cbb\u7642\u9f3b\u54bd\u764c\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u570b\u969b\u591a\u4e2d\u5fc3\u2162\u671f\u81e8\u5e8a\u7814\u7a76\uff0cNCT03581786\uff09\u53caPOLARIS-02\uff08\u4e00\u9805\u91dd\u5c0d\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u6cbb\u7642\u7684\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u7684\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c64\u3001\u2161\u671f\u95dc\u9375\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff0cNCT02915432\uff09\u7684\u7814\u7a76\u7d50\u679c\u3002<\/p>\n\n\n\n<p><a>\u5176\u4e2d\uff0c<\/a>JUPITER-02\u662f\u9f3b\u54bd\u764c\u514d\u75ab\u6cbb\u7642\u9818\u57df\u9996\u500b\u570b\u969b\u591a\u4e2d\u5fc3\u3001\u6a23\u672c\u91cf\u6700\u5927\u7684\u96d9\u76f2\u3001\u96a8\u6a5f\u5c0d\u7167\u2162\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u4e5f\u662f\u5168\u7403\u9996\u500b\u9f3b\u54bd\u764c\u4e00\u7dda\u514d\u75ab\u806f\u5408\u5316\u7642\u5c0d\u6bd4\u55ae\u7d14\u5316\u7642\u5c07\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u9810\u8a2d\u6709\u7d71\u8a08\u5b78\u6aa2\u9a57\uff08\u4e00\u985e\u932f\u8aa4\u63a7\u5236\uff09\u4e26\u78ba\u8b49\u5177\u6709\u751f\u5b58\u7372\u76ca\u7684\u2162\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u5176\u7814\u7a76\u7d50\u679c\u66fe\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u4eae\u76f82021\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u5168\u9ad4\u5927\u6703\uff08#LBA2\uff09\uff0c\u96a8\u5f8c\u69ae\u767b\u300a\u81ea\u7136-\u91ab\u5b78\u300b\uff08<em>Nature Medicine<\/em>\uff0c\u5f71\u97ff\u56e0\u6578\uff1a58.7\uff09\u96dc\u8a8c\u5c01\u9762\uff0c\u4e26\u7372\u5f97\u300a\u7f8e\u570b\u91ab\u5b78\u6703\u96dc\u8a8c\u300b\uff08<em>Journal of the American Medical Association<\/em>\uff0c<em>JAMA<\/em>\uff0c\u5f71\u97ff\u56e0\u6578\uff1a63.1\uff09\u5168\u6587\u767c\u8868\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u8207\u55ae\u7d14\u5316\u7642\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u4f7f\u60a3\u8005\u7684\u75be\u75c5\u9032\u5c55\u98a8\u96aa\u964d\u4f4e48%\uff0c\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e37%\u3002\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u7d44\u7684\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5c0d\u6bd4\u55ae\u7d14\u5316\u7642\u5ef6\u9577\u4e8613.2\u500b\u6708\uff0c\u5f9e8.2\u500b\u6708\u63d0\u5347\u523021.4\u500b\u6708\u3002\u6b64\u5916\uff0c\u63a5\u53d7\u8a72\u806f\u5408\u7642\u6cd5\u6cbb\u7642\u7684\u60a3\u8005\u53ef\u7372\u5f97\u66f4\u9ad8\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u548c\u66f4\u9577\u7684\u6301\u7e8c\u7de9\u89e3\u6642\u9593\uff08DoR\uff09\uff0c\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u7387\u9054\u523026.7%\uff0c\u4e14\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u9577\u671f\u751f\u5b58\u96a8\u8a2a\u8cc7\u6599\u57282024\u5e74ASCO\u5e74\u6703\u5c55\u793a\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u7d445\u5e74\u751f\u5b58\u7387\u9054\u523052.0%\u3002<\/p>\n\n\n\n<p>POLARIS-02\u7814\u7a76\u7d50\u679c\u5df2\u65bc2021\u5e741\u6708\u7dda\u4e0a\u767c\u8868\u65bc\u300a\u81e8\u5e8a\u816b\u7624\u5b78\u96dc\u8a8c\u300b\uff08<em>Journal of Clinical Oncology<\/em>\uff0c\u5f71\u97ff\u56e0\u6578\uff1a42.1\uff09\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5728\u65e2\u5f80\u5316\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u4e2d\u8868\u73fe\u51fa\u6301\u4e45\u7684\u6297\u816b\u7624\u6d3b\u6027\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u60a3\u8005ORR\u70ba20.5%\uff0cDoR\u70ba12.8\u500b\u6708\uff0c\u4e2d\u4f4dOS\u905417.4\u500b\u6708\u3002<\/p>\n\n\n\n<p>\u622a\u81f3\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5df2\u5728\u5168\u7403\u56db\u5927\u6d32\u8d85\u904e35\u500b\u570b\u5bb6\u548c\u5730\u5340\u7372\u6279\u591a\u9805\u9069\u61c9\u75c7\uff0c\u5305\u62ec\u4e2d\u570b\u5167\u5730\u3001\u4e2d\u570b\u9999\u6e2f\u3001\u7f8e\u570b\u3001\u6b50\u76df\u3001\u82f1\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u5370\u5ea6\u3001\u7d04\u65e6\u7b49\u3002<\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><em>1. <\/em><em>\u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/em><em><\/em><\/h6>\n\n\n\n<h6 class=\"wp-block-heading\"><em>2. <\/em><em>\u82e5\u60a8\u60f3\u77ad\u89e3\u5177\u9ad4\u75be\u75c5\u8a3a\u7642\u8cc7\u8a0a\uff0c\u8acb\u9075\u5f9e\u91ab\u7642\u885b\u751f\u5c08\u696d\u4eba\u58eb\u7684\u610f\u898b\u8207\u6307\u5c0e\u3002<\/em><em><\/em><\/h6>\n\n\n\n<p><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">1. https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/cancers\/4-nasopharynx-fact-sheet.pdf.<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">2. 2025NCCN \u81e8\u5e8a\u5be6\u8e10\u6307\u5357\uff1a\u982d\u9838\u90e8\u816b\u7624\uff082025.V1\uff09.<\/h5>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u95dc\u65bc\u7279\u745e\u666e\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<\/strong><strong><sup>\u00ae<\/sup><\/strong><strong>\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u7279\u745e\u666e\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<sup>\u00ae<\/sup>\uff09\u4f5c\u70ba\u6211\u570b\u6279\u51c6\u4e0a\u5e02\u7684\u9996\u500b\u570b\u7522\u4ee5PD-1\u70ba\u9776\u9ede\u7684\u55ae\u6297\u85e5\u7269\uff0c\u7372\u5f97\u570b\u5bb6\u79d1\u6280\u91cd\u5927\u5c08\u9805\u5c08\u6848\u652f\u6301\uff0c\u4e26\u69ae\u81ba\u570b\u5bb6\u5c08\u5229\u9818\u57df\u6700\u9ad8\u734e\u9805\u201c\u4e2d\u570b\u5c08\u5229\u91d1\u734e\u201d\u3002<\/p>\n\n\n\n<p>\u7279\u745e\u666e\u5229\u55ae\u6297\u81f3\u4eca\u5df2\u5728\u5168\u7403\uff08\u5305\u62ec\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6b50\u6d32\u53ca\u6771\u5357\u4e9e\u7b49\u5730\uff09\u958b\u5c55\u4e86\u8986\u84cb\u8d85\u904e15\u500b\u9069\u61c9\u75c7\u768440\u591a\u9805\u7531\u516c\u53f8\u767c\u8d77\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u6b63\u5728\u9032\u884c\u6216\u5df2\u5b8c\u6210\u7684\u95dc\u9375\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\u5728\u591a\u500b\u7624\u7a2e\u7bc4\u570d\u5167\u8a55\u4f30\u7279\u745e\u666e\u5229\u55ae\u6297\u7684\u5b89\u5168\u6027\u53ca\u7642\u6548\uff0c\u5305\u62ec\u80ba\u764c\u3001\u9f3b\u54bd\u764c\u3001\u98df\u7ba1\u764c\u3001\u80c3\u764c\u3001\u8180\u80f1\u764c\u3001\u4e73\u817a\u764c\u3001\u809d\u764c\u3001\u814e\u764c\u53ca\u76ae\u819a\u764c\u7b49\u3002<\/p>\n\n\n\n<p>\u622a\u81f3\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5df2\u5728\u4e2d\u570b\u5167\u5730\u7372\u627910\u9805\u9069\u61c9\u75c7\uff1a\u7528\u65bc\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u7cfb\u7d71\u6cbb\u7642\u5931\u6557\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7642\uff082018\u5e7412\u6708\uff09\uff1b\u7528\u65bc\u65e2\u5f80\u63a5\u53d7\u904e\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u7cfb\u7d71\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u6cbb\u7642\uff082021\u5e742\u6708\uff09\uff1b\u7528\u65bc\u542b\u9251\u5316\u7642\u5931\u6557\u5305\u62ec\u65b0\u8f14\u52a9\u6216\u8f14\u52a9\u5316\u764212\u500b\u6708\u5167\u9032\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u6cbb\u7642\uff082021\u5e744\u6708\uff09\uff1b\u806f\u5408\u9806\u9251\u548c\u5409\u897f\u4ed6\u6ff1\u7528\u65bc\u5c40\u90e8\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff082021\u5e7411\u6708\uff09\uff1b\u806f\u5408\u7d2b\u6749\u9187\u548c\u9806\u9251\u7528\u65bc\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\/\u5fa9\u767c\u6216\u9060\u8655\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u764c\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff082022\u5e745\u6708\uff09\uff1b\u806f\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u9251\u985e\u7528\u65bc\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad4\uff08EGFR\uff09\u57fa\u56e0\u7a81\u8b8a\u9670\u6027\u548c\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9670\u6027\u3001\u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff082022\u5e749\u6708\uff09\uff1b\u806f\u5408\u5316\u7642\u570d\u624b\u8853\u671f\u6cbb\u7642\uff0c\u7e7c\u4e4b\u672c\u54c1\u55ae\u85e5\u4f5c\u70ba\u8f14\u52a9\u6cbb\u7642\uff0c\u7528\u65bc\u53ef\u5207\u9664IIIA-IIIB\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u6210\u4eba\u60a3\u8005\uff082023\u5e7412\u6708\uff09\uff1b\u806f\u5408\u963f\u6614\u66ff\u5c3c\u7528\u65bc\u4e2d\u9ad8\u5371\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u814e\u7d30\u80de\u764c\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff082024\u5e744\u6708\uff09\uff1b\u806f\u5408\u4f9d\u8a17\u6cca\u82f7\u548c\u9251\u985e\u7528\u65bc\u5ee3\u6cdb\u671f\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\uff082024\u5e746\u6708\uff09\uff1b\u806f\u5408\u6ce8\u5c04\u7528\u7d2b\u6749\u9187\uff08\u767d\u86cb\u767d\u7d50\u5408\u578b\uff09\u7528\u65bc\u7d93\u5145\u5206\u9a57\u8b49\u7684\u6aa2\u6e2c\u8a55\u4f30PD-L1\u967d\u6027\uff08CPS\u22651\uff09\u7684\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u4e09\u9670\u6027\u4e73\u817a\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff082024\u5e746\u6708\uff09\u30022020\u5e7412\u6708\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u9996\u6b21\u901a\u904e\u570b\u5bb6\u91ab\u4fdd\u8ac7\u5224\uff0c\u76ee\u524d\u5df2\u670910\u9805\u7372\u6279\u9069\u61c9\u75c7\u7d0d\u5165\u300a\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\uff082024\u5e74\uff09\u300b\uff0c\u662f\u76ee\u9304\u4e2d\u552f\u4e00\u7528\u65bc\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u570d\u624b\u8853\u671f\u3001\u814e\u764c\u3001\u4e09\u9670\u6027\u4e73\u817a\u764c\u6cbb\u7642\u7684\u6297PD-1\u55ae\u6297\u85e5\u7269\u30022024\u5e7410\u6708\uff0c\u7279\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class=\"wp-block-heading\"><em>1. <\/em><em>\u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/em><em><\/em><\/h6>\n\n\n\n<h6 class=\"wp-block-heading\"><em>2. <\/em><em>\u82e5\u60a8\u60f3\u77ad\u89e3\u5177\u9ad4\u75be\u75c5\u8a3a\u7642\u8cc7\u8a0a\uff0c\u8acb\u9075\u5f9e\u91ab\u7642\u885b\u751f\u5c08\u696d\u4eba\u58eb\u7684\u610f\u898b\u8207\u6307\u5c0e\u3002<\/em><em><\/em><\/h6>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u95dc\u65bc\u6c2b\u6eb4\u9178\u6c18\u745e\u7c73\u5fb7\u97cb\u7247\uff08\u6c11\u5f97\u7dad<\/strong><strong><sup>\u00ae<\/sup><\/strong><strong>\uff0c<\/strong><strong>VV116\/JT001<\/strong><strong>\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u6c11\u5f97\u7dad<sup>\u00ae<\/sup>\u662f\u4e00\u6b3e\u53e3\u670d\u6838\u82f7\u985e\u85e5\u7269\uff0c\u53ef\u6291\u5236SARS-CoV-2\u8907\u88fd\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\uff0c\u6c11\u5f97\u7dad<sup>\u00ae<\/sup>\u5c0d\u5305\u62ec\u5967\u5bc6\u514b\u620e\u5728\u5167\u7684\u65b0\u51a0\u75c5\u6bd2\u539f\u59cb\u682a\u548c\u7a81\u8b8a\u682a\u8868\u73fe\u51fa\u986f\u8457\u7684\u6297\u75c5\u6bd2\u4f5c\u7528\uff0c\u4e14\u7121\u907a\u50b3\u6bd2\u6027\u3002\u8a72\u7522\u54c1\u7531\u4e2d\u570b\u79d1\u5b78\u9662\u4e0a\u6d77\u85e5\u7269\u7814\u7a76\u6240\u3001\u4e2d\u570b\u79d1\u5b78\u9662\u6b66\u6f22\u75c5\u6bd2\u7814\u7a76\u6240\u3001\u4e2d\u570b\u79d1\u5b78\u9662\u65b0\u7586\u7406\u5316\u6280\u8853\u7814\u7a76\u6240\u3001\u4e2d\u570b\u79d1\u5b78\u9662\u4e2d\u4e9e\u85e5\u7269\u7814\u767c\u4e2d\u5fc3\/\u4e2d\u70cf\u91ab\u85e5\u79d1\u6280\u57ce\uff08\u79d1\u6280\u90e8\u201c\u4e00\u5e36\u4e00\u8def\u201d\u806f\u5408\u5be6\u9a57\u5ba4\uff09\u3001\u81e8\u6e2f\u5be6\u9a57\u5ba4\u3001\u8607\u5dde\u65fa\u5c71\u65fa\u6c34\u751f\u7269\u91ab\u85e5\u6709\u9650\u516c\u53f8\u548c\u541b\u5be6\u751f\u7269\u5171\u540c\u7814\u767c\u3002<\/p>\n\n\n\n<p>\u5728\u65b0\u51a0\u75ab\u60c5\u671f\u9593\uff0c\u6c11\u5f97\u7dad<sup>\u00ae<\/sup>\u5728\u570b\u5167\u5916\u958b\u5c55\u4e86\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u3002\u4e00\u9805\u5728\u4f34\u6709\u9032\u5c55\u70ba\u91cd\u75c7\u9ad8\u98a8\u96aa\u56e0\u7d20\u7684\u8f15\u4e2d\u5ea6COVID-19\u60a3\u8005\u4e2d\u5c0d\u6bd4PAXLOVID\u7528\u65bc\u8f15\u4e2d\u5ea6COVID-19\u65e9\u671f\u6cbb\u7642\u7684\u2162\u671f\u81e8\u5e8a\u7814\u7a76\uff08JT001-010\uff09\u7372\u5f97\u570b\u969b\u6b0a\u5a01\u671f\u520a\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\uff08<em>The New England Journal of Medicine<\/em>\uff0cIF\uff1a96.2\uff09\u767c\u8868<sup>[1]<\/sup>\uff0c\u53e6\u4e00\u9805\u5728\u4f34\u6216\u4e0d\u4f34\u6709\u9032\u5c55\u70ba\u91cd\u75c7\u9ad8\u98a8\u96aa\u56e0\u7d20\u7684\u8f15\u4e2d\u5ea6COVID-19\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u2162\u671f\u81e8\u5e8a\u7814\u7a76\uff08JT001-015\uff09\u7372\u5f97\u570b\u969b\u9802\u5c16\u611f\u67d3\u75c5\u5b78\u671f\u520a\u300a\u67f3\u8449\u5200-\u611f\u67d3\u75c5\u5b78\u300b\uff08<em>The Lancet Infectious Diseases<\/em>\uff0cIF\uff1a36.4\uff09\u767c\u8868<sup>[2]<\/sup>\u3002<\/p>\n\n\n\n<p>2021\u5e7412\u6708\uff0c\u6c11\u5f97\u7dad<sup>\u00ae<\/sup>\u5728\u70cf\u8332\u5225\u514b\u65af\u5766\u7372\u5f97\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u4e2d\/\u91cd\u5ea6COVID-19\u60a3\u8005\u3002<\/p>\n\n\n\n<p>2023\u5e741\u6708\uff0c\u6c11\u5f97\u7dad<sup>\u00ae<\/sup>\u5728\u4e2d\u570b\u7372\u5f97\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u8f15\u4e2d\u5ea6COVID-19\u7684\u6210\u5e74\u60a3\u8005\uff0c\u4e26\u4e8e2023\u5e741\u6708\u8d77\u81e8\u6642\u6027\u7d0d\u5165\u91ab\u4fdd\u652f\u4ed8\u7bc4\u570d\uff0c2024\u5e741\u6708\u8d77\u7d0d\u5165\u6b63\u5f0f\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">[1] Cao Z, Gao W, Bao H, et al. VV116 versus Nirmatrelvir\u2013Ritonavir for Oral Treatment of Covid-19. N Engl J Med. DOI: 10.1056\/NEJMoa2208822.<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">[2] Xiaohong Fan, Xiahong Dai, Yun Ling, et al. Oral VV116 versus placebo in patients with mild-to-moderate COVID-19 in China: a multicentre, double-blind, phase 3, randomised controlled study. The Lancet Infectious Diseases. DOI:10.1016\/S1473-3099(23)00577-7.<\/h5>\n","protected":false},"excerpt":{"rendered":"<p>\u7528\u65bc\u6cbb\u7642\u8f15\u4e2d\u5ea6\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u611f\u67d3\uff08COVID-19\uff09\u7684\u6210\u5e74\u60a3\u8005<\/p>\n","protected":false},"author":4,"featured_media":3217,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[],"class_list":["post-3223","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-21"],"yoast_head":"\n<title>\u541b\u5be6\u751f\u7269\u5ba3\u4f48\u6c11\u5f97\u7dad\u00ae\u6cbb\u7642\u65b0\u51a0\u7372\u5e38\u898f\u6279\u51c6 - \u541b\u5b9e\u751f\u7269<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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class=\"wp-block-heading\">\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">1. \u76db\u932b\u6960\u3001\u9ec3\u92fc\u3001\u65b9\u7f8e\u7389\u7b49\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5c0d\u6bd4\u9054\u5361\u5df4\u55ea\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u9ed1\u8272\u7d20\u7624\uff1a\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u5c0d\u7167\u3001\u958b\u653e\u6a19\u7c64\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u30022024\u5e74\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u5b78\u8853\u5e74\u6703\u3002<\/h5>\n\n\n\n<p><\/p>\n\n\n\n<h6 class=\"wp-block-heading\"><em>1. <\/em>\u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\"><em>2. 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class=\"wp-block-heading\">1. https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/cancers\/16-melanoma-of-skin-fact-sheet.pdf.<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">2. https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/160-china-fact-sheet.pdf.<\/h5>\n\n\n\n<h5 class=\"wp-block-heading\">3. 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